Lung cancer susceptibility locus at 5p15.33

被引：464

作者：

McKay, James D. ^{[1
]}

Hung, Rayjean J. ^{[1
,2
]}

Gaborieau, Valerie ^{[1
]}

Boffetta, Paolo ^{[1
]}

Chabrier, Amelie ^{[1
]}

Byrnes, Graham ^{[1
]}

Zaridze, David ^{[3
]}

Mukeria, Anush ^{[3
]}

Szeszenia-Dabrowska, Neonilia ^{[4
]}

Lissowska, Jolanta ^{[5
,6
]}

Rudnai, Peter ^{[7
]}

Fabianova, Eleonora ^{[8
]}

Mates, Dana ^{[9
]}

Bencko, Vladimir ^{[10
]}

Foretova, Lenka ^{[11
]}

Janout, Vladimir ^{[12
]}

McLaughlin, John ^{[2
,13
]}

Shepherd, Frances ^{[14
]}

Montpetit, Alexandre ^{[15
,16
]}

Narod, Steven ^{[17
]}

Krokan, Hans E. ^{[18
]}

Skorpen, Frank ^{[18
]}

Elvestad, Maiken Bratt ^{[18
]}

Vatten, Lars ^{[18
]}

Njolstad, Inger ^{[19
]}

Axelsson, Tomas ^{[20
]}

Chen, Chu ^{[21
]}

Goodman, Gary ^{[21
]}

Barnett, Matt ^{[21
]}

Loomis, Melissa M. ^{[21
]}

Lubinski, Jan ^{[22
]}

Matyjasik, Joanna ^{[22
]}

Lener, Marcin ^{[22
]}

Oszutowska, Dorota ^{[22
]}

Field, John ^{[23
]}

Liloglou, Triantafillos ^{[23
]}

Xinarianos, George ^{[23
]}

Cassidy, Adrian ^{[23
]}

Zelenika, Diana ^{[24
]}

Boland, Anne ^{[24
]}

Delepine, Marc ^{[24
]}

Foglio, Mario ^{[24
]}

Lechner, Doris ^{[24
]}

Matsuda, Fumihiko ^{[24
]}

Blanche, Helene ^{[25
]}

Gut, Ivo ^{[24
]}

Heath, Simon ^{[24
]}

Lathrop, Mark ^{[24
,25
]}

Brennan, Paul ^{[1
]}

机构：

[1] Int Agcy Res Canc, F-69008 Lyon, France

[2] Samuel Lunenfeld Res Inst, Toronto, ON M5T 3L9, Canada

[3] Russian Acad Med Sci, Canc Res Ctr, Inst Carcinogenesis, Moscow 115478, Russia

[4] Inst Occupat Med, Dept Epidemiol, PL-90950 Lodz, Poland

[5] M Sklodowska Curie Mem Canc Ctr, PL-02781 Warsaw, Poland

[6] Inst Oncol, PL-02781 Warsaw, Poland

[7] Natl Inst Environm Hlth, H-1097 Budapest, Hungary

[8] Specialized Inst Hyg & Epidemiol, Banska Bystrica 97556, Slovakia

[9] Inst Publ Hlth, Bucharest 050463, Romania

[10] Charles Univ Prague, Fac Med 1, Inst Hyg & Epidemiol, Prague 12800 2, Czech Republic

[11] Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno 65653, Czech Republic

[12] Palacky Univ, Olomouc 77515, Czech Republic

[13] Canc Care Ontario, Toronto, ON M5G 2L7, Canada

[14] Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

[15] McGill Univ, Montreal, PQ H3A 1A4, Canada

[16] Genome Quebec Innovat Ctr, Montreal, PQ H3A 1A4, Canada

[17] Womens Coll Res Inst, Toronto, ON M5G 1N8, Canada

[18] Norwegian Univ Sci & Technol, N-7489 Trondheim, Norway

[19] Univ Tromso, Inst Community Med, N-9037 Tromso, Norway

[20] Uppsala Univ, Acad Hosp, Dept Med Sci, SNP Technol Platform, Uppsala 75185, Sweden

[21] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[22] Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland

[23] Univ Liverpool, Canc Res Ctr, Roy Castle Lung Canc Res Programme, Liverpool L3 9TA, Merseyside, England

[24] CEA, Inst Genom, Ctr Natl Genotypage, F-91000 Evry, France

[25] Fdn Jean Dausset CEPH, F-75010 Paris, France

来源：

NATURE GENETICS | 2008年 / 40卷 / 12期

关键词：

D O I：

10.1038/ng.254

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We carried out a genome-wide association study of lung cancer (3,259 cases and 4,159 controls), followed by replication in 2,899 cases and 5,573 controls. Two uncorrelated disease markers at 5p15.33, rs402710 and rs2736100 were detected by the genome-wide data (P - 2 x 10(-7) and P = 4 x 10(-6)) and replicated by the independent study series (P = 7 x 10(-5) and P = 0.016). The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.

引用

页码：1404 / 1406

页数：3

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