Synthesis of indolocarbazole quinones;: potent aryl hydrocarbon receptor ligands

被引：31

作者：

Bergman, J

Wahlström, N

Yudina, LN

Tholander, J

Lidgren, G

机构：

[1] Sodertorn Univ, Karolinska Inst, Dept Biosci Novum, Unit Organ Chem, SE-14157 Huddinge, Sweden

[2] Sodertorn Univ Coll, SE-14101 Huddinge, Sweden

[3] AstraZeneca R&D, Dept Med Chem, SE-43183 Molndal, Sweden

[4] Swedish Pharmaceut Soc, SE-11181 Stockholm, Sweden

来源：

TETRAHEDRON | 2002年 / 58卷 / 07期

关键词：

indole; quinone; carbazole; Ah receptor;

D O I：

10.1016/S0040-4020(02)00006-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of indolo[2,3-b]carbazole-6,12-dione and the isomeric indolo[3,2-b]carbazole-6,12-dione, an extremely efficient inducer of the aryl hydrocarbon (Ah) receptor are described. Initial oxidation of the parent indolo[3,2-b]carbazole followed by several different ring-closing strategies produced the latter compound. Entries into syntheses of unsymmetrical 6,12-disubstituted indolo[2,3-b]carbazoles are also described. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1443 / 1452

页数：10

共 48 条

[1] Cytochromes P450 and metabolism of xenobiotics [J].