Enhanced levels in neonatal rat liver of 7,8-dihydro-8-oxo-2'deoxyguanosine (8-hydroxydeoxyguanosine), a major mutagenic oxidative DNA lesion

被引:31
作者
Randerath, K
Zhou, GD
Monk, SA
Randerath, E
机构
[1] Division of Toxicology, Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, One Baylor Plaza
关键词
D O I
10.1093/carcin/18.7.1419
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period, P-32-postlabeling showed this adduct to increase similar to 2-fold from the 20th day of gestation (2 days before birth) to a peak level at 50-53 h after birth, Postnatal levels exceeded fetal levels at all time points investigated, i.e. 0.5-1, 8, 24, 50-53, 100, 216 and 432 h after birth, Increased formation of this mutagenic DNA lesion during the critical postnatal phase when there is rapid cell proliferation in all tissues is proposed to contribute to carcinogenesis in susceptible tissues later in life.
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页码:1419 / 1421
页数:3
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