Role of cell surface molecules of Blastomyces dermatitidis in host-pathogen interactions

被引：17

作者：

Klein, BS

Newman, SL

机构：

[1] UNIV WISCONSIN, SCH MED, DEPT PEDIAT, MADISON, WI 53792 USA

[2] UNIV WISCONSIN, SCH MED, DEPT INTERNAL MED, MADISON, WI 53792 USA

[3] UNIV WISCONSIN, SCH MED, DEPT MED MICROBIOL & IMMUNOL, MADISON, WI 53792 USA

[4] UNIV WISCONSIN, SCH MED, CTR COMPREHENS CANC, MADISON, WI 53792 USA

[5] UNIV CINCINNATI, COLL MED, DEPT MED, DIV INFECT DIS, CINCINNATI, OH 45267 USA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0966-842X(96)10028-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fungal pathogen Blastomyces dermatitidis produces an adhesin (WI-1) in yeast stages, which contains repetitive regions that bind host-cell receptors. Adhesin and glucan may modulate fungal interactions with macrophages; their level of expression is altered in hypovirulent mutants. Adhesin is also involved in immune responses, and may be important in eliciting the clearance of the fungus.

引用

页码：246 / 251

页数：6

共 40 条

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