Structure and function of fibronectin modules

被引:161
作者
Potts, JR [1 ]
Campbell, ID [1 ]
机构
[1] UNIV OXFORD,DEPT BIOCHEM,OXFORD OX1 3QU,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1016/S0945-053X(96)90133-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fibronectin is an important component of the extracellular matrix and is involved in a diverse range of physiological processes. It is a mosaic protein composed almost entirely of: three types of module, F1, F2 and F3. Although the structures of single F1, F2 and F3 modules have been available for a number of years, in many cases the key to understanding the structure-function relationships in fibronectin and other proteins containing these modules lies in studies of module pairs and larger domains. This review focuses on recent advances in the understanding of the structure and function of fibronectin modules.
引用
收藏
页码:313 / 320
页数:8
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