Porphyria cutanea tarda as a complication of therapy for chronic hepatitis C

被引：14

作者：

Azim, James ^{[1
,2
]}

McCurdy, Heather ^{[1
,2
]}

Moseley, Richard H. ^{[1
,2
]}

机构：

[1] Dept Vet Affairs Med Ctr, Div Gastroenterol, Dept Internal Med, Ann Arbor, MI USA

[2] Univ Michigan, Sch Med, Ann Arbor, MI USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2008年 / 14卷 / 38期

关键词：

Porphyria; Hepatitis C virus; Ribavirin; Pegylated interferon; Hemochromatosis;

D O I：

10.3748/wjg.14.5913

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is a strong association between porphyria cutanea tarda (PCT) and chronic viral hepatitis C. Therapy for chronic viral hepatitis C may improve PCT. However, there are only a few reports of the de novo development of PCT during therapy for chronic viral hepatitis C. We describe the development of PCT in a 56-year-old patient with chronic viral hepatitis C after 12 wk of peginterferon/ribavirin therapy. In addition, the patient was homozygous for the H63D hereditary hemochromatosis gene (HFE) mutation. The association of PCT with chronic viral hepatitis C and the possible role of hepatic iron overload and ribavirin-induced hemolytic anemia in the development of PCT during therapy for chronic viral hepatitis C are discussed. (C) 2008 The WIG Press. All rights reserved.

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页码：5913 / 5915

页数：3

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