Mass spectrometry MALDI imaging of colon cancer biomarkers: a new diagnostic paradigm

被引：23

作者：

Pevsner, Paul H. ^{[1
]}

Melamed, Jonathan ^{[2
]}

Remsen, Tiffany ^{[1
]}

Kogos, Alexander ^{[1
]}

Francois, Fritz ^{[3
]}

Kessler, Paul ^{[1
]}

Stern, Arnold ^{[1
]}

Anand, Sury ^{[4
]}

机构：

[1] NYU, Sch Med, Dept Pharmacol, New York, NY 10003 USA

[2] NYU, Sch Med, Dept Pathol, New York, NY USA

[3] NYU, Sch Med, Dept Med, Div Gastroenterol, New York, NY USA

[4] Brooklyn Hosp Ctr, Div Gastroenterol, Dept Pharmacol, Brooklyn, NY USA

来源：

BIOMARKERS IN MEDICINE | 2009年 / 3卷 / 01期

关键词：

biomarker; colorectal cancer; imaging; LCMS; liquid chromatography mass spectrometry; MALDI IMS; mass spectrometry; matrix-assisted laser desorption/ionization imaging mass spectrometry; HUMAN CHORIONIC-GONADOTROPIN; DIRECT TISSUE-ANALYSIS; COLORECTAL-CANCER; APOPTOSIS; PROTEINS; MUCOSA; EXPRESSION; CELLS; MS; IDENTIFICATION;

D O I：

10.2217/17520363.3.1.55

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Colorectal cancer (CRC), is the second-leading cause of cancer-related deaths in the USA, affecting both men and women. Current projections show little or no change since the publication of a morbidity and mortality study in 2005. The projected number of new cases for 2008 is 154,000, and the projected number of CRC cancer deaths for 2008 is 53,000. The standard diagnostic paradigm is based on histopathology of either biopsy or surgical specimens. This article suggests a new paradigm for colon cancer diagnosis and staging using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS or IMS). IMS may identify potential tumors in normal tissue of cancer patients and predict those cancer patients who are at risk for recurrent cancer.

引用

页码：55 / 69

页数：15

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