Rearrangement/hypermutation/gene conversion: When, where and why?

被引：79

作者：

Weill, JC

Reynaud, CA

机构：

[1] INSERM U373, Institut Necker, Université Paris 5, 75730 Paris Cedex 15

来源：

IMMUNOLOGY TODAY | 1996年 / 17卷 / 02期

关键词：

D O I：

10.1016/0167-5699(96)80586-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Diversification strategies for immunoglobulins vary widely in different species. Here, Jean-Claude Weill and Claude-Agnes Reynaud argue that V(D)J recombination arose as a means for achieving allelic exclusion rather than diversity, and postulate that the choice of a diversification strategy is selected along with a specific site of B-cell differentiation. They propose that somatic mutation and gene conversion represent analogous molecular strategies occurring in specific chromatin accessibility contexts.

引用

页码：92 / 97

页数：6

共 37 条

[1] GENERATION OF IMMUNOGLOBULIN LIGHT-CHAIN GENE DIVERSITY IN RAJA-ERINACEA IS NOT ASSOCIATED WITH SOMATIC REARRANGEMENT, AN EXCEPTION TO A CENTRAL PARADIGM OF B-CELL IMMUNITY
ANDERSON, MK
SHAMBLOTT, MJ
LITMAN, RT
LITMAN, GW
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) : 109 - 119
[2] APPENDIX OF RABBIT - A HOMOLOGUE OF BURSA IN CHICKEN
ARCHER, OK
SUTHERLAND, DE
GOOD, RA
[J]. NATURE, 1963, 200 (490) : 337 - +
[3] MOLECULAR EVOLUTION OF THE VERTEBRATE IMMUNE-SYSTEM
BARTL, S
BALTIMORE, D
WEISSMAN, IL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (23) : 10769 - 10770
[4] ORIGIN OF ANTIBODY VARIATION
BRENNER, S
MILSTEIN, C
[J]. NATURE, 1966, 211 (5046) : 242 - &
[5] THE ORIGIN OF MUTANTS
CAIRNS, J
OVERBAUGH, J
MILLER, S
[J]. NATURE, 1988, 335 (6186) : 142 - 145
[6] ALLELIC INACTIVATION REGULATES OLFACTORY RECEPTOR GENE-EXPRESSION
CHESS, A
SIMON, I
CEDAR, H
AXEL, R
[J]. CELL, 1994, 78 (05) : 823 - 834
[7] MOLECULAR BASIS OF ANTIBODY FORMATION - A PARADOX
DREYER, WJ
BENNETT, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (03) : 864 - +
[8] SOMATIC RECOMBINATION OF DUPLICATED GENES - AN HYPOTHESIS ON ORIGIN OF ANTIBODY DIVERSITY
EDELMAN, GM
GALLY, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 57 (02) : 353 - &
[9] Ferradini L, 1994, Semin Immunol, V6, P165, DOI 10.1006/smim.1994.1022
[10] GHAFFARI SH, 1991, J IMMUNOL, V146, P1037

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