The outdoor air pollution and brain health workshop

被引：434

作者：

Block, Michelle L. ^{[1
]}

Elder, Alison ^{[2
]}

Auten, Richard L. ^{[3
]}

Bilbo, Staci D. ^{[4
]}

Chen, Honglei ^{[5
]}

Chen, Jiu-Chiuan ^{[6
]}

Cory-Slechta, Deborah A. ^{[2
]}

Costa, Daniel ^{[7
]}

Diaz-Sanchez, David ^{[8
]}

Dorman, David C. ^{[9
]}

Gold, Diane R. ^{[10
]}

Gray, Kimberly

Jeng, Hueiwang Anna ^{[11
]}

Kaufman, Joel D. ^{[12
]}

Kleinman, Michael T. ^{[13
]}

Kirshner, Annette

Lawler, Cindy

Miller, David S. ^{[14
]}

Nadadur, Srikanth S.

Ritz, Beate ^{[15
]}

Semmens, Erin O. ^{[16
]}

Tonelli, Leonardo H. ^{[17
]}

Veronesi, Bellina ^{[18
]}

Wright, Robert O. ^{[19
]}

Wright, Rosalind J. ^{[19
]}

机构：

[1] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA 23298 USA

[2] Univ Rochester, Dept Environm Med, Rochester, NY USA

[3] Duke Univ, Dept Pediat, Div Neonatol, Durham, NC 27706 USA

[4] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA

[5] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA

[6] Univ So Calif, Keck Sch Med, Dept Preventat Med, Los Angeles, CA 90033 USA

[7] US EPA, Off Res & Dev, Res Triangle Pk, NC 27711 USA

[8] US EPA, Environm Publ Hlth Div, NHEERL, Res Triangle Pk, NC 27711 USA

[9] N Carolina State Univ, Coll Vet Med, Dept Mol Biomed Sci, Raleigh, NC USA

[10] Harvard Univ, Brigham & Womens Hosp, Channing Lab, Dept Med,Med Sch, Boston, MA 02115 USA

[11] Old Dominion Univ, Coll Hlth Sci, Sch Community & Environm Hlth, Norfolk, VA USA

[12] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA

[13] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA

[14] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA

[15] Univ Calif Los Angeles, Dept Epidemiol, Ctr Occupat & Environm Hlth, Los Angeles, CA USA

[16] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[17] Univ Maryland, Sch Med, Mood & Anxiety Program LT, Dept Psychiat, Baltimore, MD 21201 USA

[18] US EPA, Natl Hlth & Environm Effects Lab, Integrated Syst Toxicol Div, Res Triangle Pk, NC 27711 USA

[19] Mt Sinai Sch Med, New York, NY USA

来源：

NEUROTOXICOLOGY | 2012年 / 33卷 / 05期

关键词：

Air pollution; Brain; Particulate matter; Ozone; Central nervous system; Susceptibility; Epidemiology; Neuroinflammation; Neurotoxicity; Behavior; CENTRAL-NERVOUS-SYSTEM; AMBIENT PARTICULATE MATTER; DIESEL EXHAUST PARTICLES; HEART-RATE-VARIABILITY; EARLY ENVIRONMENTAL-REGULATION; RECEPTOR GENE-EXPRESSION; LEFT-VENTRICULAR MASS; GENOMIC TARGET SITES; LONG-TERM EXPOSURE; RAT NASAL-MUCOSA;

D O I：

10.1016/j.neuro.2012.08.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Accumulating evidence suggests that outdoor air pollution may have a significant impact on central nervous system (CNS) health and disease. To address this issue, the National Institute of Environmental Health Sciences/National Institute of Health convened a panel of research scientists that was assigned the task of identifying research gaps and priority goals essential for advancing this growing field and addressing an emerging human health concern. Here, we review recent findings that have established the effects of inhaled air pollutants in the brain, explore the potential mechanisms driving these phenomena, and discuss the recommended research priorities/approaches that were identified by the panel. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：972 / 984

页数：13

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