The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease

被引：239

作者：

Bai, Peter ^{[1
,2
]}

Canto, Carles ^{[3
]}

机构：

[1] Univ Debrecen, Med & Hlth Sci Ctr, Dept Med Chem, H-4032 Debrecen, Hungary

[2] Hungarian Acad Sci, Cell Biol & Signaling Res Grp, H-4032 Debrecen, Hungary

[3] Nestle Inst Hlth Sci, CH-1015 Lausanne, Switzerland

来源：

CELL METABOLISM | 2012年 / 16卷 / 03期

关键词：

POLY(ADP-RIBOSE) POLYMERASE 1; ADIPOCYTE FUNCTION; DIFFERENTIATION; EXPRESSION; NAD(+); GENE;

D O I：

10.1016/j.cmet.2012.06.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

While originally described as DNA damage repair agents, recent data suggest a role for poly(ADP-ribose) polymerase (PARP) enzymes in metabolic regulation by influencing mitochondrial function and oxidative metabolism. Here we review how PARP activity has a major metabolic impact and the role of PARP-1 and PARP-2 in diverse metabolic complications.

引用

页码：290 / 295

页数：6

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