Oxidative damage on RNA mediated by cationic metalloporphyrin antisense oligonucleotides conjugates

被引：15

作者：

Duarte, V

Sixou, S

Favre, G

Pratviel, G

Meunier, B

机构：

[1] CTR CLAUDIUS REGAUD, F-31052 TOULOUSE, FRANCE

[2] FAC PHARM, LAB ONCOL CELLULAIRE & MOL, F-31052 TOULOUSE, FRANCE

[3] CNRS, CHIM COORDINAT LAB, F-31077 TOULOUSE 4, FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS | 1997年 / 21期

关键词：

D O I：

10.1039/a704743f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A manganese cationic porphyrin covalently linked to the 5' end of an antisense oligonucleotide was shown to mediate sequence-specific oxidative lesions on a mRNA target when activated by KHSO5. This manganese porphyrin cleaver did not induce direct RNA strand breaks but promoted the arrest of reverse transcription due to oxidative damage on bases of the RNA template.

引用

收藏

页码：4113 / 4118

页数：6

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