The actin-ADP-ribosylating Clostridium botulinum C2 toxin

被引：11

作者：

Aktories, K ^{[1
]}

Barth, H ^{[1
]}

机构：

[1] Univ Freiburg, Inst Expt & Clin Pharmakol & Toxikol, D-79104 Freiburg, Germany

来源：

ANAEROBE | 2004年 / 10卷 / 02期

关键词：

D O I：

10.1016/j.anaerobe.2003.10.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clostridium botulinum C2 toxin is the prototype of actin-ADP-ribosylating toxins. The toxin consists of the enzyme component C2I and the separated binding/translocation component C2II. C2II is proteolytically activated to form heptamers, which bind the enzyme component. After endocytosis of the receptor toxin complex, the enzyme component enters the cytosol from an acidic endosomal compartment to modify G-actin at arginine177. Recent data indicate that chaperons are involved in the translocation process of the toxin. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：101 / 105

页数：5

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