Patients with aspergilloma can be safely managed with supportive therapy in absence of massive haemoptysis. We hypothesised that chronic cavitary pulmonary aspergillosis (CCPA) could also be managed on similar grounds. The aim of this prospective, randomised controlled trial was to evaluate the efficacy and safety of itraconazole in CCPA. Consecutive patients of CCPA with presence of chronic pulmonary/systemic symptoms; and pulmonary cavities; and presence of Aspergillus (immunological or microbiological) were randomised to receive either supportive treatment alone or itraconazole 400 mg daily for 6 months plus supportive therapy. Response was assessed clinically, radiologically and overall after 6 months therapy. A total of 31 patients (mean age, 37 years) were randomised to itraconazole (n = 17) or the control (n = 14) group. The number of patients showing overall response was significantly higher in the itraconazole group (76.5%) vs. the control (35.7%) group (P = 0.02). The numbers of patients demonstrating clinical or radiological response were also significantly higher in the itraconazole group (P = 0.016 and 0.01 respectively). Adverse events were noted in eight patients in the itraconazole group, however, none was serious or led to discontinuation of the study drug. Itraconazole was found to be superior to standard supportive treatment alone in stabilising cases of CCPA. (clinicaltrials. gov; NCT01259336).
机构:
Hop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Cadranel, J.
Philippe, B.
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机构:
Hop Rene Dubos, Serv Pneumol, F-95300 Pontoise, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Philippe, B.
Hennequin, C.
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机构:
Univ Paris 06, UMR S945, F-75005 Paris, France
INSERM, U945, Paris, France
Hop St Antoine, AP HP, Serv Parasitol Mycol, F-75571 Paris, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Hennequin, C.
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Bergeron, A.
Bergot, E.
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机构:
Hop Cote Nacre, Serv Pneumol, F-14033 Caen, France
Univ Caen, ER INSERM Canc & Populat, F-14000 Caen, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Bergot, E.
Bourdin, A.
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h-index: 0
机构:
Ctr Hosp Univ, Dept Resp Dis, F-34090 Montpellier, France
Univ Montpellier 1&2, INSERM, U1046, F-34000 Montpellier, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Bourdin, A.
Cottin, V.
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机构:
Hop Louis Pradel, Hosp Civils Lyon, F-69677 Bron, France
Univ Lyon 1, UMR 754, F-69100 Villeurbanne, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Cottin, V.
Jeanfaivre, T.
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h-index: 0
机构:
CHU Angers, Dept Pneumol, F-49933 Angers, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Jeanfaivre, T.
Godet, C.
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机构:
Hop Mil, Serv Malad Infect, F-86021 Poitiers, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Godet, C.
Pineau, M.
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h-index: 0
机构:
Pfizer Global Pharmaceut, F-75668 Paris, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Pineau, M.
Germaud, P.
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机构:
Hop Laennec, Inst Thorax, Serv Pneumol, F-44093 Nantes, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
机构:
Univ S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, EnglandUniv S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, England
Denning, David W.
Pleuvry, Alex
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机构:Univ S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, England
Pleuvry, Alex
Cole, Donald C.
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h-index: 0
机构:
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, CanadaUniv S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, England
机构:
N Manchester Grp Hosp, Dept Trop Med & Infect Dis, Manchester, Lancs, EnglandN Manchester Grp Hosp, Dept Trop Med & Infect Dis, Manchester, Lancs, England
机构:
Hop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Cadranel, J.
Philippe, B.
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h-index: 0
机构:
Hop Rene Dubos, Serv Pneumol, F-95300 Pontoise, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Philippe, B.
Hennequin, C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, UMR S945, F-75005 Paris, France
INSERM, U945, Paris, France
Hop St Antoine, AP HP, Serv Parasitol Mycol, F-75571 Paris, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Hennequin, C.
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机构:
Bergeron, A.
Bergot, E.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Cote Nacre, Serv Pneumol, F-14033 Caen, France
Univ Caen, ER INSERM Canc & Populat, F-14000 Caen, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Bergot, E.
Bourdin, A.
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Hosp Univ, Dept Resp Dis, F-34090 Montpellier, France
Univ Montpellier 1&2, INSERM, U1046, F-34000 Montpellier, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Bourdin, A.
Cottin, V.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Louis Pradel, Hosp Civils Lyon, F-69677 Bron, France
Univ Lyon 1, UMR 754, F-69100 Villeurbanne, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Cottin, V.
Jeanfaivre, T.
论文数: 0引用数: 0
h-index: 0
机构:
CHU Angers, Dept Pneumol, F-49933 Angers, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Jeanfaivre, T.
Godet, C.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Mil, Serv Malad Infect, F-86021 Poitiers, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Godet, C.
Pineau, M.
论文数: 0引用数: 0
h-index: 0
机构:
Pfizer Global Pharmaceut, F-75668 Paris, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
Pineau, M.
Germaud, P.
论文数: 0引用数: 0
h-index: 0
机构:
Hop Laennec, Inst Thorax, Serv Pneumol, F-44093 Nantes, FranceHop Tenon, AP HP, Serv Pneumol & Reanimat, F-75020 Paris, France
机构:
Univ S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, EnglandUniv S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, England
Denning, David W.
Pleuvry, Alex
论文数: 0引用数: 0
h-index: 0
机构:Univ S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, England
Pleuvry, Alex
Cole, Donald C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, CanadaUniv S Manchester Hosp, Natl Aspergillosis Ctr, Manchester M23 9LT, Lancs, England
机构:
N Manchester Grp Hosp, Dept Trop Med & Infect Dis, Manchester, Lancs, EnglandN Manchester Grp Hosp, Dept Trop Med & Infect Dis, Manchester, Lancs, England