Synthesis and anti-cancer activities of a pair of enantiomeric gold(I) complexes containing sulfanyl-substituted P-stereogenic phosphines

被引：23

作者：

Song, YC

Vittal, JJ

Srinivasan, N

Chan, SH

Leung, PH ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Chem, Kent Ridge 1119260, Singapore

[2] Natl Univ Singapore, Dept Microbiol, Kent Ridge 1119260, Singapore

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(99)00106-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A pair of enantiomeric gold(I) complexes containing enantiomerically pure 2,3-dimethyl-7-pheny1-5-(phenylsulfanyl)-7-(R/S)-phosphabicyclo[2.2.1]hept-2-ene has been prepared and in vitro cytotoxicity tests showed that both the enantiomers are relatively nontoxic against healthy lymphocytes, but are highly potent against suspension and monolayer human tumor cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1433 / 1436

页数：4

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