Macrophages and epithelial cells respond differently to the Pseudomonas aeruginosa type III secretion system

被引：63

作者：

Coburn, J

Frank, DW

机构：

[1] Tufts Univ, New England Med Ctr, Div Rheumatol & Immunol, Boston, MA 02111 USA

[2] Med Coll Wisconsin, Dept Microbiol, Milwaukee, WI 53226 USA

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 06期

关键词：

D O I：

10.1128/IAI.67.6.3151-3154.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The multiple effects of Pseudomonas aeruginosa type III secretion have largely been attributed to variations in cytotoxin expression between strains. Here we show that the target cell type is also important. While lung epithelial cells showed significant changes in morphology but not viability when infected with P. aeruginosa, macrophages were efficiently killed by P. aeruginosa. Both responses were dependent on the type III secretion system.

引用

收藏

页码：3151 / 3154

页数：4

相关论文

共 21 条

[1] EXOENZYME-S OF PSEUDOMONAS-AERUGINOSA ADP-RIBOSYLATES THE INTERMEDIATE FILAMENT PROTEIN VIMENTIN [J].

COBURN, J ;

DILLON, ST ;

IGLEWSKI, BH ;

GILL, DM .

INFECTION AND IMMUNITY, 1989, 57 (03) :996-998

[2]

COBURN J, 1989, J BIOL CHEM, V264, P9004

[3] ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury [J].

FinckBarbancon, V ;

Goranson, J ;

Zhu, L ;

Sawa, T ;

WienerKronish, JP ;

Fleiszig, SMJ ;

Wu, C ;

MendeMueller, L ;

Frank, DW .

MOLECULAR MICROBIOLOGY, 1997, 25 (03) :547-557

[4]

FINCKBARBANCON V, UNPUB

[5] Pseudomonas aeruginosa-mediated cytotoxicity and invasion correlate with distinct genotypes at the loci encoding exoenzyme S [J].

Fleiszig, SMJ ;

WienerKronish, JP ;

Miyazaki, H ;

Vallas, V ;

Mostov, KE ;

Kanada, D ;

Sawa, T ;

Yen, TSB ;

Frank, DW .

INFECTION AND IMMUNITY, 1997, 65 (02) :579-586

[6] The exoenzyme S regulon of Pseudomonas aeruginosa [J].

Frank, DW .

MOLECULAR MICROBIOLOGY, 1997, 26 (04) :621-629

[7] PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence [J].

Hauser, AR ;

Kang, PJ ;

Engel, JN .

MOLECULAR MICROBIOLOGY, 1998, 27 (04) :807-818

[8] Type III protein secretion systems in bacterial pathogens of animals and plants [J].

Hueck, CJ .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 1998, 62 (02) :379-+

[9] FUNCTIONAL DOMAINS OF PSEUDOMONAS-AERUGINOSA EXOENZYME-S [J].

KNIGHT, DA ;

FINCKBARBANCON, V ;

KULICH, SM ;

BARBIERI, JT .

INFECTION AND IMMUNITY, 1995, 63 (08) :3182-3186

[10] Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa [J].

Liu, SY ;

Yahr, TL ;

Frank, DW ;

Barbieri, JT .

JOURNAL OF BACTERIOLOGY, 1997, 179 (05) :1609-1613