Hepatitis B Virus Infection and the Dialysis Patient

被引：48

作者：

Fabrizi, Fabrizio ^{[1
,2
]}

Messa, Piergiorgio ^{[1
]}

Martin, Paul ^{[2
]}

机构：

[1] IRCCS, Osped Maggiore, Div Nefrol & Dialisi, I-20122 Milan, Italy

[2] Univ Miami, Ctr Liver Dis, Miami, FL USA

来源：

SEMINARS IN DIALYSIS | 2008年 / 21卷 / 05期

关键词：

D O I：

10.1111/j.1525-139X.2008.00437.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Prevention of nosocomical transmission of hepatitis B virus (HBV) has been a signal achievement ill the management of chronic kidney disease. The rate of serum hepatitis B surface antigen (HBsAg) seropositivity in patients on maintenance hemodialysis in the developed world is currently low (0-10%) but outbreaks of acute HBV infection continue to occur in this setting. The prevalence of HBV infection within dialysis units in developing countries appears higher (2-20%) based on relatively few reports. Although data are limited, HBV infection in dialysis population diminishes survival: HBV viral load in HBsAg-positive dialysis p patients is reportedly low and stable over time. Updated recommendations for the management of HBsAg chronic carriers on maintenance dialysis have been issued. No rigorously controlled treatment trials for treatment of hepatitis B with either interferon or lamivudine therapy ill dialysis patients are currently available.

引用

页码：440 / 446

页数：7

共 7 条

[1] An open-label study of lamivudine for chronic hepatitis B in six patients with chronic renal failure before and after kidney transplantation [J].

Ben-Ari, Z ;

Broida, E ;

Kittai, Y ;

Chagnac, A ;

Tur-Kaspa, R .

AMERICAN JOURNAL OF GASTROENTEROLOGY, 2000, 95 (12) :3579-3583

[2] Hepatitis virus infection in haemodialysis patients from Moldavia [J].

Covic, A ;

Iancu, L ;

Apetrei, C ;

Scripcaru, D ;

Volovat, C ;

Mititiuc, I ;

Covic, M .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1999, 14 (01) :40-45

[3] HBV genotypic resistance to lamivudine in kidney recipients and hemodialyzed patients [J].

Fontaine, H ;

Thiers, V ;

Chrétien, Y ;

Zylberberg, H ;

Poupon, RE ;

Bréchot, C ;

Legendre, C ;

Kreis, H ;

Pol, S .

TRANSPLANTATION, 2000, 69 (10) :2090-2094

[4] Efficacy and safety of adefovir dipivoxil in kidney recipients, hemodialysis patients, and patients with renal insufficiency [J].

Fontaine, HL ;

Vallet-Pichard, A ;

Chaix, ML ;

Currie, G ;

Serpaggi, J ;

Verkarre, V ;

Varaut, A ;

Morales, E ;

Nalpas, B ;

Brosgart, C ;

Pol, S .

TRANSPLANTATION, 2005, 80 (08) :1086-1092

[5] Viral hepatitis B [J].

Lai, CL ;

Ratziu, V ;

Yuen, MF ;

Poynard, T .

LANCET, 2003, 362 (9401) :2089-2094

[6]

ROSTAING C, 1998, CLIN IMPLICATIONS SM, V9, P2144

[7] Excellent outcome of lamivudine treatment in patients with chronic renal failure and hepatitis B virus infection [J].

Schmilovitz-Weiss, H ;

Melzer, E ;

Tur-Kaspa, R ;

Ben-Ari, Z .

JOURNAL OF CLINICAL GASTROENTEROLOGY, 2003, 37 (01) :64-67

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