Total synthesis of (±)-8′-trifluoromethyl abscisic acid

被引：10

作者：

Balko, TW ^{[1
]}

Fields, SC ^{[1
]}

Webster, JD ^{[1
]}

机构：

[1] Dow AgroSci, Dow Venture Ctr, Discovery Res, Indianapolis, IN 46268 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(99)01206-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

While 8'-trifluoromethyl ABA (2a) was known to be one of the most active and stable analogs tested in assays for ABA-like activity, a thorough evaluation of its biological properties was limited by compound availability. The current synthesis, which includes the preparation of a previously unknown key intermediate 2-methyl-2- trifluoromethyl-1,4-cyclohexanedione-mono ethylene ketal (18), has been accomplished in 14 steps and 3% yield. The key fluorinated ketal intermediate 18 was prepared in six steps and 20% yield. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：6347 / 6351

页数：5

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