Noninvasive transcranial direct current stimulation over the left prefrontal cortex facilitates cognitive flexibility in tool use

被引：165

作者：

Chrysikou, Evangelia G. ^{[1
,2
]}

Hamilton, Roy H. ^{[3
]}

Coslett, H. Branch ^{[3
]}

Datta, Abhishek ^{[4
]}

Bikson, Marom ^{[4
]}

Thompson-Schill, Sharon L. ^{[1
]}

机构：

[1] Univ Penn, Dept Psychol, Ctr Cognit Neurosci, Philadelphia, PA 19104 USA

[2] Univ Kansas, Dept Psychol, Lawrence, KS 66045 USA

[3] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

[4] CUNY City Coll, Dept Biomed Engn, New York, NY 10031 USA

来源：

COGNITIVE NEUROSCIENCE | 2013年 / 4卷 / 02期

关键词：

Semantic memory; Creative cognition; Transcranial direct current stimulation; Prefrontal cortex; Cognitive control; MEMORY; CATEGORIZATION; EXCITABILITY; ENHANCEMENT; PERFORMANCE; APHASIA; LESS; TDCS;

D O I：

10.1080/17588928.2013.768221

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Recent neuroscience evidence suggests that some higher-order tasks might benefit from a reduction in sensory filtering associated with low levels of cognitive control. Guided by neuroimaging findings, we hypothesized that cathodal (inhibitory) transcranial direct current stimulation (tDCS) will facilitate performance in a flexible use generation task. Participants saw pictures of artifacts and generated aloud either the object's common use or an uncommon use for it, while receiving cathodal tDCS (1.5mA) either over left or right PFC, or sham stimulation. A forward digit span task served as a negative control for potential general effects of stimulation. Analysis of voice-onset reaction times and number of responses generated showed significant facilitative effects of left PFC stimulation for the uncommon, but not the common use generation task and no effects of stimulation on the control task. The results support the hypothesis that certain tasks may benefit from a state of diminished cognitive control.

引用

页码：81 / 89

页数：9

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