Genetic diversity of invasive strains of Haemophilus influenzae type b before and after introduction of the conjugate vaccine in Italy

被引：7

作者：

Cerquetti, Marina

Cardines, Rita

Giufre, Maria

Sofia, Tonino

D'Ambrosio, Fabio

Mastrantonio, Paola

Atti, Marta Luisa Ciofi degli

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immune Mediated Dis, I-00161 Rome, Italy

[2] Ist Super Sanita, Natl Ctr Epidemiol Surveillance & Hlth Promot, I-00161 Rome, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2006年 / 43卷 / 03期

关键词：

D O I：

10.1086/505499

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We determined the genotypes of 95 invasive Haemophilus influenzae type b (Hib) strains collected before and after introduction of widespread Hib vaccination in Italy. No substantial change in genetic diversity was highlighted by pulsed-field gel electrophoresis. However, an upward temporal trend in proportion of strains possessing multiple copies of the capsulation b locus was detected (P = .03).

引用

收藏

页码：317 / 319

页数：3

相关论文

共 12 条

[1] Molecular epidemiology of Haemophilus influenzae type b isolated from children with clinical cases of conjugate vaccine failures [J].

Campos, J ;

Aracil, B ;

Román, F ;

Pérez-Vázquez, M .

JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (08) :3915-3918

[2] Presence of multiple copies of the capsulation b locus in invasive Haemophilus influenzae type B (Hib) strains isolated from children with Hib conjugate vaccine failure [J].

Cerquetti, M ;

Cardines, R ;

delgi Atti, MLC ;

Giufré, M ;

Bella, A ;

Sofia, T ;

Mastrantonio, P ;

Slack, M .

JOURNAL OF INFECTIOUS DISEASES, 2005, 192 (05) :819-823

[3]

Cerquetti M, 2003, EMERG INFECT DIS, V9, P258

[4] GENES INVOLVED IN HAEMOPHILUS-INFLUENZAE TYPE-B CAPSULE EXPRESSION ARE FREQUENTLY AMPLIFIED [J].

CORN, PG ;

ANDERS, J ;

TAKALA, AK ;

KAYHTY, H ;

HOISETH, SK .

JOURNAL OF INFECTIOUS DISEASES, 1993, 167 (02) :356-364

[5] PCR FOR CAPSULAR TYPING OF HAEMOPHILUS-INFLUENZAE [J].

FALLA, TJ ;

CROOK, DWM ;

BROPHY, LN ;

MASKELL, D ;

KROLL, JS ;

MOXON, ER .

JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (10) :2382-2386

[6] Clinical and immunological risk factors associated with Haemophilus influenzae type b conjugate vaccine failure in childhood [J].

Heath, PT ;

Booy, R ;

Griffiths, H ;

Clutterbuck, E ;

Azzopardi, HJ ;

Slack, MPE ;

Fogarty, J ;

Moloney, AC ;

Moxon, ER .

CLINICAL INFECTIOUS DISEASES, 2000, 31 (04) :973-980

[7] The UK Hib vaccine experience [J].

Heath, PT ;

McVernon, J .

ARCHIVES OF DISEASE IN CHILDHOOD, 2002, 86 (06) :396-399

[8] Risk of vaccine failure after Haemophilus influenzae type b (Hib) combination vaccines with acellular pertussis [J].

McVernon, J ;

Andrews, N ;

Slack, MPE ;

Ramsay, ME .

LANCET, 2003, 361 (9368) :1521-1523

[9] Return of Haemophilus influenzae type b infections [J].

Rijkers, GT ;

Vermeer-de Bondt, PE ;

Spanjaard, L ;

Breukels, MA ;

Sanders, EAM .

LANCET, 2003, 361 (9368) :1563-1564

[10] Increase in genetic diversity of Haemophilus influenzae serotype b (Hib) strains after introduction of hib vaccination in the Netherlands [J].

Schouls, LM ;

van der Ende, A ;

van de Pol, I ;

Schot, C ;

Spanjaard, L ;

Vauterin, P ;

Wilderbeek, D ;

Witteveen, S .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (06) :2741-2749