Versatile synthesis of inhibitors of late enzymes in the bacterial pathway to lysine

被引:11
作者
Steger, M [1 ]
Young, DW [1 ]
机构
[1] Univ Sussex, CPES, Sussex Ctr Biomol Design & Drug Dev, Brighton BN1 9QJ, E Sussex, England
关键词
D O I
10.1016/S0040-4020(99)00403-2
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Modification of our 'ring switching' reaction has allowed us to develop a versatile synthesis of potential inhibitors of the late enzymes in the bacterial pathway to lysine. The methodology is applicable to solid phase combinatorial synthesis. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:7935 / 7956
页数:22
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