Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder

被引:87
作者
van Dyck, CH
Quinlan, DM
Cretella, LM
Staley, JK
Malison, RT
Baldwin, RM
Seibyl, JP
Innis, RB
机构
[1] Yale Univ, Sch Med, Dept Psychiat, Cognit Disorders Clin, New Haven, CT 06510 USA
[2] Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT 06510 USA
[3] W Haven Vet Affairs Med Ctr, West Haven, CT USA
关键词
D O I
10.1176/appi.ajp.159.2.309
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striataldopamine transporter levels, which may explain psychostimulant effects in this disorder. Method: Single photon emission computed tomography and [I-123]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([I-123]beta-CIT) were used to assess dopamine transporter availability in nine adult patients with ADHD (eight of whom were stimulant naive) and nine age- and gender-matched healthy comparison subjects. Results: Striatal [I-123]beta-CIT binding did not differ significantly between the ADHD and comparison subjects. Conclusions: The findings suggest that a hypothesized dysregulation of dopamine function in ADHD does not entail altered dopamine transporter levels.
引用
收藏
页码:309 / 312
页数:4
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