Intellectual ability and cortical development in children and adolescents

被引:1053
作者
Shaw, P [1 ]
Greenstein, D
Lerch, J
Clasen, L
Lenroot, R
Gogtay, N
Evans, A
Rapoport, J
Giedd, J
机构
[1] NIMH, Child Psychiat Branch, Bethesda, MD 20182 USA
[2] McGill Univ, Montreal Neurol Inst, Montreal, PQ H3A 2B4, Canada
关键词
D O I
10.1038/nature04513
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Children who are adept at any one of the three academic 'R's ( reading, writing and arithmetic) tend to be good at the others, and grow into adults who are similarly skilled at diverse intellectually demanding activities(1-3). Determining the neuroanatomical correlates of this relatively stable individual trait of general intelligence has proved difficult, particularly in the rapidly developing brains of children and adolescents. Here we demonstrate that the trajectory of change in the thickness of the cerebral cortex, rather than cortical thickness itself, is most closely related to level of intelligence. Using a longitudinal design, we find a marked developmental shift from a predominantly negative correlation between intelligence and cortical thickness in early childhood to a positive correlation in late childhood and beyond. Additionally, level of intelligence is associated with the trajectory of cortical development, primarily in frontal regions implicated in the maturation of intelligent activity(4,5). More intelligent children demonstrate a particularly plastic cortex, with an initial accelerated and prolonged phase of cortical increase, which yields to equally vigorous cortical thinning by early adolescence. This study indicates that the neuroanatomical expression of intelligence in children is dynamic.
引用
收藏
页码:676 / 679
页数:4
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