Nitric oxide synthase inhibition blocks phencyclidine-induced behavioural effects on prepulse inhibition and locomotor activity in the rat

被引:78
作者
Johansson, C [1 ]
Jackson, DM [1 ]
Svensson, L [1 ]
机构
[1] GOTHENBURG UNIV,DEPT PHARMACOL,GOTHENBURG,SWEDEN
基金
英国医学研究理事会;
关键词
nitric oxide; prepulse inhibition; locomotor activity; schizophrenia; phencyclidine; amphetamine; rat;
D O I
10.1007/s002130050280
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The ability of the nitric oxide synthase inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME), to block the behavioural effects of the potent psychotomimetic, phencyclidine, was tested in rats using two different behavioural models. L-NAME was found to block both phencyclidine-induced disruption of prepulse inhibition of acoustic startle and phencyclidine-induced stimulation of locomotor activity. A selective action of L-NAME on the effects of phencyclidine was indicated, since L-NAME did not alter the effects of amphetamine, another potent psychotomimetic, in these behavioural models, These observations suggest that a nitric oxide-dependent mechanism may be involved in the effects of phencyclidine in the central nervous system.
引用
收藏
页码:167 / 173
页数:7
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