Non-viral gene delivery systems

被引：363

作者：

Davis, ME ^{[1
]}

机构：

[1] CALTECH, Pasadena, CA 91125 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0958-1669(02)00294-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-viral gene delivery systems have the potential to create viable pharmaceuticals from nucleic acids. These DNA delivery systems contain lipids and/or cationic polymers. In order for these systems to be developed into commercial products, several barriers must be overcome. These include obstacles in manufacturing, formulation and stability. In vivo, problems of extracellular non-specific interactions and intracellular trafficking to the nucleus are also encountered. Recent progress has been made in overcoming these issues.

引用

页码：128 / 131

页数：4

共 35 条

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