Reduced tolerance to certain pharmacological effects of ethanol after chronic administration in perinatally undernourished rats

被引：7

作者：

Cordoba, NE ^{[1
]}

Borghese, CM ^{[1
]}

Arolfo, MP ^{[1
]}

Orsingher, OA ^{[1
]}

机构：

[1] UNIV NACL CORDOBA,FAC CIENCIAS QUIM,DEPT FARMACOL,RA-5000 CORDOBA,ARGENTINA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1997年 / 57卷 / 04期

关键词：

perinatal undernutrition; chronic ethanol; tolerance; hypothermia; hypoalgesia; anticonvulsant; rat;

D O I：

10.1016/S0091-3057(96)00392-9

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We have previously reported that recovered adult rats undernourished at perinatal age failed to develop tolerance to the anticonflict effect of ethanol after chronic ethanol administration (1 g/kg/day during 30 days) (4). To further study the extent of this finding, we examined the effect of a similar chronic ethanol treatment on the hypothermic and anticonvulsant effects of ethanol in perinatally deprived rats. Hypoalgesic activity was assessed in ethanol treated rats during 15 days. After chronic ethanol treatment, a similar development of tolerance to the hypothermic effect of ethanol was observed in control and deprived rats. However, tolerance to the anticonvulsant and hypoalgesic effect of ethanol was significantly reduced in deprived as compared with control animals. Thus, early undernutrition differentially affects the development of tolerance elicited by chronic ethanol administration. (C) 1997 Elsevier Science Inc.

引用

页码：659 / 663

页数：5

共 24 条

[1] REACTIVITY TO AMPHETAMINE IN PERINATALLY UNDERNOURISHED RATS - BEHAVIORAL AND NEUROCHEMICAL CORRELATES [J].

BRIONI, JD ;

KELLER, EA ;

LEVIN, LE ;

CORDOBA, N ;

ORSINGHER, OA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, 24 (03) :449-454

[2] OPERANT-BEHAVIOR AND REACTIVITY TO THE ANTICONFLICT EFFECT OF DIAZEPAM IN PERINATALLY UNDERNOURISHED RATS [J].

BRIONI, JD ;

ORSINGHER, OA .

PHYSIOLOGY & BEHAVIOR, 1988, 44 (02) :193-198

[3] PERINATAL UNDERNUTRITION ALTERS HYPOTHERMIC RESPONSES TO DIFFERENT CENTRAL AGONISTS IN RECOVERED ADULT-RATS [J].

BRIONI, JD ;

ORSINGHER, OA .

NEUROPHARMACOLOGY, 1987, 26 (7A) :771-774

[4] PERINATAL PROTEIN-DEPRIVATION ENHANCES THE ANTICONFLICT EFFECT MEASURED AFTER CHRONIC ETHANOL ADMINISTRATION IN ADULT-RATS [J].

CORDOBA, NE ;

CUADRA, GR ;

BRIONI, JD ;

ORSINGHER, OA .

JOURNAL OF NUTRITION, 1992, 122 (07) :1536-1541

[5]

CORDOBA NE, 1990, ACTA PHYSIOL PHARM L, V40, P403

[6] VASCULAR REACTIVITY IN PERINATALLY UNDERNOURISHED RATS [J].

DELBASSO, P ;

KELLER, EA ;

SALICA, C ;

ORSINGHER, OA .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 87 (01) :107-111

[7]

KELLER EA, 1984, ARCH INT PHARMACOD T, V268, P88

[8] LACK OF ADAPTIVE-CHANGES IN 5-HT SITES IN PERINATALLY UNDERNOURISHED RATS AFTER CHRONIC STRESS - OPIOID INFLUENCE [J].

KELLER, EA ;

CANCELA, LM ;

MOLINA, VA ;

ORSINGHER, OA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1994, 47 (04) :789-793

[9] LACK OF NEURONAL ADAPTIVE-CHANGES FOLLOWING CHRONIC TREATMENTS IN PERINATALLY UNDERNOURISHED RATS [J].

KELLER, EA ;

MOLINA, VA ;

ORSINGHER, OA .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 37 (04) :675-678

[10] PERINATAL UNDERNUTRITION AFFECTS BRAIN MODULATORY CAPACITY OF BETA-ADRENERGIC RECEPTORS IN ADULT-RATS [J].

KELLER, EA ;

CUADRA, GR ;

MOLINA, VA ;

ORSINGHER, OA .

JOURNAL OF NUTRITION, 1990, 120 (03) :305-308

← 1 2 3 →