Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: A proof of concept trial

被引：195

作者：

Stefan, Hermann ^{[1
,2
]}

Kreiselmeyer, Gernot ^{[1
]}

Kerling, Frank ^{[1
]}

Kurzbuch, Katrin ^{[1
]}

Rauch, Christophe ^{[1
]}

Heers, Marcel ^{[1
]}

Kasper, Burkhard S. ^{[1
]}

Hammen, Thilo ^{[1
]}

Rzonsa, Martina ^{[1
]}

Pauli, Elisabeth ^{[1
]}

Ellrich, Jens ^{[3
,4
]}

Graf, Wolfgang ^{[1
]}

Hopfengaertner, Ruediger ^{[1
]}

机构：

[1] Univ Hosp Erlangen, Neurol Clin, Dept Neurol, Epilepsy Ctr, D-91054 Erlangen, Germany

[2] Univ Hosp Giessen & Marburg, Interdisciplinary Epilepsy Ctr, Marburg, Germany

[3] Cerbomed GmbH, Dept Med, Erlangen, Germany

[4] Aalborg Univ, Dept Hlth Sci & Technol, Aalborg, Denmark

来源：

EPILEPSIA | 2012年 / 53卷 / 07期

关键词：

Transcutaneous vagus nerve stimulation; Pharmacoresistant epilepsies; Outpatient monitoring; Automatic seizure quantification; Computerized cognitive testing in epilepsy; Neuromodulation; Neurostimulation; EEG; SEIZURES;

D O I：

10.1111/j.1528-1167.2012.03492.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To elucidate, in a pilot-study, whether noninvasive transcutaneous vagus nerve stimulation (t-VNS) is a safe and tolerable alternative treatment option in pharmacoresistant epilepsy. t-VNS was applied to 10 patients with pharmacoresistant epilepsies. Stimulation via the auricular branch of the vagus nerve of the left tragus was delivered three times per day for 9 months. Subjective documentation of stimulation effects was obtained from patients seizure diaries. For a more reliable assessment of seizure frequency, we carried out prolonged outpatient videoelectroencephalography (EEG) monitoring. In addition, computerized testing of cognitive, affective, and emotional functions was performed. Three patients aborted the study. Of the remaining seven patients, an overall reduction of seizure frequency was observed in five patients after 9 months of t-VNS. The noninvasive t-VNS stimulation is a safe and well-tolerated method for relatively long periods, and might be an alternative treatment option for patients with epilepsy.

引用

页码：e115 / e118

页数：4

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