Mantle cell lymphoma cell lines show no evident immunoglobulin heavy chain stereotypy but frequent light chain stereotypy

被引：7

作者：

Pighi, Chiara ^{[1
]}

Barbi, Stefano ^{[1
]}

Bertolaso, Anna ^{[1
]}

Zamo, Alberto ^{[1
]}

机构：

[1] Univ Verona, Dipartimento Patol & Diagnost, I-37134 Verona, Italy

来源：

LEUKEMIA & LYMPHOMA | 2013年 / 54卷 / 08期

关键词：

Mantle cell lymphoma; B-cell receptor; immunogenetics; stereotypy; CHRONIC LYMPHOCYTIC-LEUKEMIA; MARGINAL-ZONE LYMPHOMA; PARAFFIN-EMBEDDED TISSUES; REGION GENE ANALYSIS; IN-VITRO MODELS; V-H GENES; SOMATIC HYPERMUTATION; CLONAL IMMUNOGLOBULIN; ANTIGEN RECEPTORS; COLD AGGLUTININS;

D O I：

10.3109/10428194.2012.758843

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Mantle cell lymphoma shows a peculiar immunogenetic profile, but the functional consequences of this fact are unknown. We have determined the precise sequences of rearranged heavy and light chain genes in several mantle cell lymphoma cell lines and investigated the presence of heavy and light chain stereotypy. These cell lines use IGHV and IGLV genes that are known to be preferentially rearranged in mantle cell lymphoma, but we found no evidence of heavy chain stereotypy. In contrast, one cell line (Mino) showed a nearly identical light chain complementarity-determining region 3 when compared to the only published light chain cluster. Two cell line couples (Jeko-1/UPN-2 and JVM-2/JVM-13) showed a highly similar light chain that satisfied the criteria for stereotypy. Our data show that mantle cell lymphoma cell lines resemble the IGHV and IGLV usage of mantle cell lymphoma, and foster the hypothesis that light chain stereotypy might be under-recognized.

引用

页码：1747 / 1755

页数：9

共 65 条

[1]

ROUTINE APPLICATION OF POLYMERASE CHAIN-REACTION IN THE DIAGNOSIS OF MONOCLONALITY OF B-CELL LYMPHOID PROLIFERATIONS [J].

ACHILLE, A ;

SCARPA, A ;

MONTRESOR, M ;

SCARDONI, M ;

ZAMBONI, G ;

CHILOSI, M ;

CAPELLI, P ;

FRANZIN, G ;

MENESTRINA, F .

DIAGNOSTIC MOLECULAR PATHOLOGY, 1995, 4 (01) :14-24

[2]

Amin HM, 2003, ARCH PATHOL LAB MED, V127, P424

[3]

Splenic marginal zone lymphoma: Clinical clustering of immunoglobulin heavy chain repertoires [J].

Arcaini, Luca ;

Zibellini, Silvia ;

Passamonti, Francesco ;

Rattotti, Sara ;

Lucioni, Marco ;

Invernizzi, Rosangela ;

Merli, Michele ;

Rizzi, Silvia ;

Boveri, Emanuela ;

Rumi, Elisa ;

Astori, Cesare ;

Picone, Cristina ;

Varettoni, Marzia ;

Pascutto, Cristiana ;

Paulli, Marco ;

Lazzarino, Mario .

BLOOD CELLS MOLECULES AND DISEASES, 2009, 42 (03) :286-291

[4]

VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy [J].

Arons, Evgeny ;

Suntum, Tara ;

Stetler-Stevenson, Maryalice ;

Kreitman, Robert J. .

BLOOD, 2009, 114 (21) :4687-4695

[5]

Bahler, David W. ;

Szankasi, Philippe ;

Kulkarni, Sucheta ;

Tubbs, Raymond R. ;

Cook, James R. ;

Swerdlow, Steven H. .

MODERN PATHOLOGY, 2009, 22 (06) :833-838

[6]

Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling [J].

Bea, Silvia ;

Salaverria, Itziar ;

Armengol, Lluis ;

Pinyol, Magda ;

Fernandez, Veronica ;

Hartmann, Elena M. ;

Jares, Pedro ;

Amador, Virginia ;

Hernandez, Luis ;

Navarro, Alba ;

Ott, German ;

Rosenwald, Andreas ;

Estivill, Xavier ;

Campo, Elias .

BLOOD, 2009, 113 (13) :3059-3069

[7]

Immunoglobulin light chain kappa deletion rearrangement as a marker of clonality in mantle cell lymphoma [J].

Bertoni, F ;

Zucca, E ;

Genini, D ;

Cazzaniga, G ;

Roggero, E ;

Ghielmini, M ;

Cavalli, F ;

Biondi, A .

LEUKEMIA & LYMPHOMA, 1999, 36 (1-2) :147-150

[8]

Bhat NM, 2002, J RHEUMATOL, V29, P2114

[9]

Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire [J].

Bikos, V. ;

Stalika, E. ;

Baliakas, P. ;

Darzentas, N. ;

Davis, Z. ;

Traverse-Glehen, A. ;

Dagklis, A. ;

Kanellis, G. ;

Anagnostopoulos, A. ;

Tsaftaris, A. ;

Ponzoni, M. ;

Berger, F. ;

Felman, P. ;

Ghia, P. ;

Papadaki, T. ;

Oscier, D. ;

Belessi, C. ;

Stamatopoulos, K. .

LEUKEMIA, 2012, 26 (12) :2567-2569

[10]

Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications [J].

Bikos, V. ;

Darzentas, N. ;

Hadzidimitriou, A. ;

Davis, Z. ;

Hockley, S. ;

Traverse-Glehen, A. ;

Algara, P. ;

Santoro, A. ;

Gonzalez, D. ;

Mollejo, M. ;

Dagklis, A. ;

Gangemi, F. ;

Bosler, D. S. ;

Bourikas, G. ;

Anagnostopoulos, A. ;

Tsaftaris, A. ;

Iannitto, E. ;

Ponzoni, M. ;

Felman, P. ;

Berger, F. ;

Belessi, C. ;

Ghia, P. ;

Papadaki, T. ;

Dogan, A. ;

Degano, M. ;

Matutes, E. ;

Piris, M. A. ;

Oscier, D. ;

Stamatopoulos, K. .

LEUKEMIA, 2012, 26 (07) :1638-1646

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