A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats

被引：449

作者：

Salvemini, D

Wang, ZQ

Zweier, JL

Samouilov, A

Macarthur, H

Misko, TP

Currie, MG

Cuzzocrea, S

Sikorski, JA

Riley, DP

机构：

[1] MetaPhore Pharmaceut, St Louis, MO 63114 USA

[2] Monsanto Co, GD Searle & Co, Discovery Pharmacol, St Louis, MO 63167 USA

[3] Johns Hopkins Univ, Sch Med, Electron Paramagnet Resonance Ctr, Baltimore, MD 21224 USA

[4] St Louis Univ, Sch Med, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA

[5] Univ Messina, Sch Med, Inst Pharmacol, I-98123 Messina, Italy

[6] Monsanto Co, GD Searle & Co, Discovery Med Chem, St Louis, MO 63198 USA

来源：

SCIENCE | 1999年 / 286卷 / 5438期

关键词：

D O I：

10.1126/science.286.5438.304

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many human diseases are associated with the overproduction of oxygen free radicals that inflict cell damage. A manganese(II) complex with a bis(cyclohexylpyridine)-substituted macrocyclic Ligand (M40403) was designed to be a functional mimic of the superoxide dismutase (SOD) enzymes that normally remove these radicals. M40403 had high catalytic SOD activity and was chemically and biologically stable in vivo. injection of M40403 into rat models of inflammation and ischemia-reperfusion injury protected the animals against tissue damage, Such mimics may result in better clinical therapies for diseases mediated by superoxide radicals.

引用

页码：304 / 306

页数：3

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