Copeptin, adropin and irisin concentrations in breast milk and plasma of healthy women and those with gestational diabetes mellitus

被引:101
作者
Aydin, Suleyman [1 ]
Kuloglu, Tuncay [2 ]
Aydin, Suna [3 ]
机构
[1] Firat Univ, Sch Med, Dept Med Biochem, Firat Hormones Res Grp, TR-23119 Elazig, Turkey
[2] Firat Univ, Sch Med, Dept Histol & Embryol, TR-23119 Elazig, Turkey
[3] Firat Univ, Sch Med, Dept Anat, TR-23119 Elazig, Turkey
关键词
Copeptin; Adropin; Irisin; Breast milk; Gestational diabetes mellitus; GHRELIN; NESFATIN-1; PRECURSOR; PEPTIDES; BRAIN; RISK; FAT;
D O I
10.1016/j.peptides.2013.07.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Copeptin, adropin and irisin are polypeptide hormones implicated in energy homostasis and diabetes. The purposes of this study were (1) to compare the copeptin, adropin and irisin concentrations between colostrum, transitional and mature milk and plasma in lactating women with and without GDM and (2) to compare these values with those from non-lactating women. Venous blood samples were obtained before suckling from 15 healthy lactating women aged 26-30 years, 15 lactating women with GDM aged 26-32 years, and 14 age-matched controls aged 25-31 years. Colostrum, transitional milk and mature milk samples were collected just before suckling. The concentration of copeptin was determined by EIA while the concentrations of adropin and irisin were determined by ELISA. The levels of copeptin, adropin and irisin in the colostrum were significantly higher than those in transitional and mature milk samples from healthy women; also, transitional milk had higher copeptin, adropin and irisin concentrations than mature milk. The amounts of copeptin in the colostrum and transitional milk were significantly higher than in mature milk samples from women with GDM, while the amounts of adropin and irisin were significantly lower. The relative concentrations of copeptin, adropin and irisin in the plasma samples from these groups of women were similar to those in the colostrum, transitional and mature milk samples, but the latter concentrations were higher than those in the plasma. These peptides could influence the regulation of metabolic pathways and the postnatal growth and development of different organs in the newborn. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:66 / 70
页数:5
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