Highlights of a new type of intercellular communication: microvesicle-based information transfer

被引：161

作者：

Pap, E. ^{[1
]}

Pallinger, E. ^{[2
,3
]}

Pasztoi, M. ^{[1
]}

Falus, A. ^{[2
,3
]}

机构：

[1] Hungarian Acad Sci, Dept Genet Cell & Immunobiol, H-1089 Budapest, Hungary

[2] Hungarian Acad Sci, Res Grp Inflammat Biol & Immunogenom, H-1089 Budapest, Hungary

[3] Semmelweis Univ, H-1089 Budapest, Hungary

来源：

INFLAMMATION RESEARCH | 2009年 / 58卷 / 01期

关键词：

Microvesicles; Microvesicular communication; Microvesicle formation; Microvesicular functions; CIRCULATING PROCOAGULANT MICROPARTICLES; CELL-DERIVED EXOSOMES; TUMOR-RELEASED MICROVESICLES; PLATELET MICROPARTICLES; MEMBRANE MICROPARTICLES; ENDOTHELIAL-CELLS; ELEVATED LEVELS; PROTEOMIC ANALYSIS; FAS LIGAND; ACTIVATION;

D O I：

10.1007/s00011-008-8210-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Microvesicles (MVs) are membrane-covered cell fragments released by most cell types during apoptosis or activation. They are increasingly considered to play a pivotal role in information transfer between cells. Their presence and role have been proven in several physiological and pathological processes, such as immune modulation in inflammation and pregnancy, or blood coagulation and cancer. MVs represent a newly recognized system of intercellular communications. They not only may serve as prognostic markers in different diseases, but could also hold the potential to be new therapeutic targets or drug delivery systems. The present overview aims to highlight some aspects of this new means of cellular communication: "microvesicular communication".

引用

页码：1 / 8

页数：8

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