Functional analysis of autoantibodies against ADP/ATP carrier from dilated cardiomyopathy

he aim of this article is to briefly review the immunological features of the autoantibodies against ADP/ATP carrier from dilated cardiomyopathy and the potential role of the autoantibodies in cardiac tissue injury. The autoantibodies against ADP/ATP carrier were found with very high frequency in patients with dilated cardiomyopathy, and had disease- and organ-specificity. The autoantibodies cross-reacted with subunits of the calcium channel on the cardiac cell membrane. There is a close correlation between the autoantibody-titer and the hemodynamic function in patients with dilated cardiomyopathy. It can be postulated that after an autoimmune response is initiated, the circulating autoantibodies against ADP/ATP carrier disturb myocardial energy metabolism, and enhance calcium influx and calcium overload in cardiac myocytes, resulting in progressive myocyte damage. These findings indicate a new immunopathological mechanism in dilated cardiomyopathy.