Detection of preoperative serum anti-p53 antibodies in gastric cancer

被引：20

作者：

Nakajima, K ^{[1
]}

Suzuki, T ^{[1
]}

Shimada, H ^{[1
]}

Hayashi, H ^{[1
]}

Takeda, A ^{[1
]}

Ochiai, T ^{[1
]}

机构：

[1] Chiba Univ, Sch Med, Dept Surg, Chuo Ku, Chiba 2608670, Japan

来源：

TUMOR BIOLOGY | 1999年 / 20卷 / 03期

关键词：

gastric cancer; p53; mutation; anti-p53; antibody; tumor marker;

D O I：

10.1159/000030057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The presence of circulating anti-p53 antibodies (p53Ab) was investigated in 81 gastric cancer patients by ELISA. Preoperatively, anti-p53Ab were revealed in 13 cases (16%), including 3 early gastric cancers. No significant correlation of p53Ab with patient age, sex, pathological parameters and tumor markers, such as CEA and CA19-9 was observed, although p53Ab positivity tended to be associated with a higher rate of lymph node metastases (p = 0.073). We have found no significant correlation between p53Ab and poor survival rate (p = 0.325). In conclusion, we have observed that p53Ab are detectable in gastric cancer patients, even at early stages of disease, however, p53Ab have not served as a predictor of poor prognosis in gastric cancer in this series.

引用

页码：147 / 152

页数：6

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