The Clostridium difficile spo0A Gene Is a Persistence and Transmission Factor

被引：257

作者：

Deakin, Laura J. ^{[2
]}

Clare, Simon ^{[2
]}

Fagan, Robert P. ^{[3
]}

Dawson, Lisa F. ^{[4
]}

Pickard, Derek J. ^{[2
]}

West, Michael R. ^{[2
]}

Wren, Brendan W. ^{[4
]}

Fairweather, Neil F. ^{[3
]}

Dougan, Gordon ^{[2
]}

Lawley, Trevor D. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Bacterial Pathogenesis Lab, Hinxton, England

[2] Wellcome Trust Sanger Inst, Microbial Pathogenesis Lab, Hinxton, England

[3] Univ London Imperial Coll Sci Technol & Med, Ctr Mol Microbiol & Infect, London, England

[4] Univ London London Sch Hyg & Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England

来源：

INFECTION AND IMMUNITY | 2012年 / 80卷 / 08期

基金：

英国惠康基金;

关键词：

DIFFICILE-ASSOCIATED DIARRHEA; CLOSTRIDIUM-DIFFICILE; ESCHERICHIA-COLI; SEVERE DISEASE; NORTH-AMERICA; EPIDEMIOLOGY; SPORULATION; EMERGENCE; VECTORS; STRAINS;

D O I：

10.1128/IAI.00147-12

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Clostridium difficile is a major cause of chronic antibiotic-associated diarrhea and a significant health care-associated pathogen that forms highly resistant and infectious spores. Spo0A is a highly conserved transcriptional regulator that plays a key role in initiating sporulation in Bacillus and Clostridium species. Here, we use a murine model to study the role of the C. difficile spo0A gene during infection and transmission. We demonstrate that C. difficile spo0A mutant derivatives can cause intestinal disease but are unable to persist within and effectively transmit between mice. Thus, the C. difficile Spo0A protein plays a key role in persistent infection, including recurrence and host-to-host transmission in mice.

引用

页码：2704 / 2711

页数：8

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