Polycystic ovary syndrome: evidence for a primary disorder of ovarian steroidogenesis

被引:17
作者
Franks, S [1 ]
Gharani, N [1 ]
Gilling-Smith, C [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, St Marys Hosp, Sch Med, Dept Reprod Sci & Med, London W2 1PG, England
关键词
D O I
10.1016/S0960-0760(99)00044-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Polycystic ovary syndrome (PCOS) is a very common endocrinopathy of uncertain aetiology in which the most consistent biochemical abnormality is hypersecretion of androgens. In this review, evidence is presented to support the view that a primary abnormality of ovarian androgen biosynthesis provides the basis for the syndrome. PCOS is a familiar disorder and we demonstrate, in molecular genetic studies, that CYP11a, the gene coding for P450 side chain cleavage, is a key susceptibility locus for development of hyperandrogenism. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:269 / 272
页数:4
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