The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: A new face of death?

被引：93

作者：

Tan, SL

Katze, MG

机构：

[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[2] Univ Washington, Reg Primate Res Ctr, Seattle, WA 98195 USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1999年 / 19卷 / 06期

关键词：

D O I：

10.1089/107999099313677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent research has thrown a spotlight on the interferon (IFN)-induced PKR protein kinase, implicating it as an important effector of apoptosis induced by several cellular stress conditions, including viral infection, cytokine treatment, and growth factor deprivation. In this review, we summarize the evidence for the role of PKR as a death accomplice and discuss how PKR might promote cell demise in light of current knowledge of the molecular mechanisms of apoptosis. Given its new found role and its established antiviral function, it is no wonder that PKR is a popular target for viral evasion of the host defense. PKR-dependent apoptosis may offer a novel cell-death pathway for specific manipulation in therapeutic strategies against apoptosis-related diseases.

引用

页码：543 / 554

页数：12

共 122 条

[1] The murine PKR tumor suppressor gene is rearranged in a lymphocytic leukemia
Abraham, N
Jaramillo, ML
Duncan, PI
Méthot, N
Icely, PL
Stojdl, DF
Barber, GN
Bell, JC
[J]. EXPERIMENTAL CELL RESEARCH, 1998, 244 (02) : 394 - 404
[2] Depletion of intracellular Ca2+ stores, phosphorylation of eIF2α, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole
Aktas, H
Flückiger, R
Acosta, JA
Savage, JM
Palakurthi, SS
Halperin, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (14) : 8280 - 8285
[3] Phosphorylation of initiation factor 2 alpha subunit and apoptosis in Ca2+ ionophore-treated cultured neuronal cells
Alcazar, A
Bazan, E
Rivera, J
Salinas, M
[J]. NEUROSCIENCE LETTERS, 1995, 201 (03) : 215 - 218
[4] Alcazar A, 1997, J NEUROCHEM, V69, P1703
[5] Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling
Balachandran, S
Kim, CN
Yeh, WC
Mak, TW
Bhalla, K
Barber, GN
[J]. EMBO JOURNAL, 1998, 17 (23) : 6888 - 6902
[6] TRANSLATIONAL REGULATION BY THE INTERFERON-INDUCED DOUBLE-STRANDED-RNA-ACTIVATED 68-KDA PROTEIN-KINASE
BARBER, GN
WAMBACH, M
WONG, ML
DEVER, TE
HINNEBUSCH, AG
KATZE, MG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) : 4621 - 4625
[7] CHROMOSOMAL ASSIGNMENT OF THE INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN-KINASE (PRKR) TO HUMAN CHROMOSOME-2P21-P22 AND MOUSE CHROMOSOME-17 E2
BARBER, GN
EDELHOFF, S
KATZE, MG
DISTECHE, CM
[J]. GENOMICS, 1993, 16 (03) : 765 - 767
[8] BARBER GN, 1995, MOL CELL BIOL, V15, P3138
[9] DETECTION OF PROTEIN-KINASE HOMOLOGS AND VIRAL RNA-BINDING DOMAINS UTILIZING POLYCLONAL ANTISERUM PREPARED AGAINST A BACULOVIRUS-EXPRESSED DS RNA-ACTIVATED 68,000-DA PROTEIN-KINASE
BARBER, GN
TOMITA, J
GARFINKEL, MS
MEURS, E
HOVANESSIAN, A
KATZE, MG
[J]. VIROLOGY, 1992, 191 (02) : 670 - 679
[10] MOLECULAR MECHANISMS RESPONSIBLE FOR MALIGNANT TRANSFORMATION BY REGULATORY AND CATALYTIC DOMAIN VARIANTS OF THE INTERFERON-INDUCED ENZYME RNA-DEPENDENT PROTEIN-KINASE
BARBER, GN
JAGUS, R
MEURS, EF
HOVANESSIAN, AG
KATZE, MG
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (29) : 17423 - 17428

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