Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1β in chimpanzees

被引：2

作者：

Dekkers, PEP

Levi, M

van Deventer, SJH

Van der Poll, T

机构：

[1] Univ Amsterdam, Acad Med Ctr, Lab Expt Internal Med, NL-1105 AZ Amsterdam, Netherlands

[2] Ctr Hemostasis Thrombosis Atherosclerosis & Infla, Amsterdam, Netherlands

来源：

INFECTION AND IMMUNITY | 1999年 / 67卷 / 10期

关键词：

D O I：

10.1128/IAI.67.10.5480-5482.1999

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1 beta (MIP-1 beta) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1 beta. Levels of MIP-1 beta and MCP-1 release were differentially regulated during endotoxemia.

引用

页码：5480 / 5482

页数：3

共 16 条

[1]

ANDERSON BO, 1991, SURG GYNECOL OBSTET, V172, P415

[2] PLASMA-LEVELS OF THE CHEMOKINES MONOCYTE CHEMOTACTIC PROTEIN-1 AND PROTEIN-2 ARE ELEVATED IN HUMAN SEPSIS [J].