Comparison of 3, 5 and 7 days' treatment with Quinimax(TM) for falciparum malaria in Guinea-Bissau

被引:17
作者
Kofoed, PE
Mapaba, E
Lopes, F
Pussick, F
Aaby, P
Rombo, L
机构
[1] MALARSJUKHUSET,DIV INFECT DIS PULM MED & DERMATOL,ESKILSTUNA,SWEDEN
[2] STATE SERUM INST,DANISH EPIDEMIOL SCI CTR,EPIDEMIOL RES UNIT,COPENHAGEN,DENMARK
关键词
malaria; Plasmodium falciparum; chemotherapy; Quinimax(TM); Guinea-Bissau;
D O I
10.1016/S0035-9203(97)90286-8
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Far treatment of malaria, the World Health Organization recommends 10 mg of quinine per kg bodyweight 3 times a day for at least 7 d. In Guinea-Bissau, as in several other African countries, a 3 d treatment regimen (10 mg/kg twice daily) is currently used. We therefore compared the 3 d treatment period with periods of 5 and 7 d. A total of 145 children with clinical malaria due to monoinfection with Plasmodium falciparum, with greater than or equal to 20 parasites per 200 leucocytes, were treated with intramuscular Quinimax(TM) 10 mg per kg body-weight twice daily for 5, 5 or 7 d. The children were then examined once weekly for 4 weeks. Following the 3 d treatment regimen, 34 of 43 children (79%) had parasitaemia on day 28 or before; following the 5 d treatment regimen, 36 of 40 children (90%) did so; and following the 3 d treatment regimen, 7 of 62 children (11%) were parasitaemic at that time. This study thus suggests that the currently recommended 3 d Quinimax(TM) treatment regimen in Guinea-Bissau for moderate and severe malaria is not effective.
引用
收藏
页码:462 / 464
页数:3
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