Optimization of aceclofenac-loaded pectinate-poly(vinyl pyrrolidone) beads by response surface methodology

被引：22

作者：

Nayak, Amit Kumar ^{[1
]}

Kalia, Samir ^{[1
]}

Hasnain, M. Saquib ^{[2
]}

机构：

[1] Seemanta Inst Pharmaceut Sci, Mayurbhanj 757086, Odisha, India

[2] Shivdan Singh Inst Technol & Management, Aligarh 202002, Uttar Pradesh, India

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2013年 / 62卷

关键词：

Pectin; Poly(vinyl pyrrolidone); Drug release; IN-VITRO; SUSTAINED-RELEASE; BLEND MICROPARTICLES; CALCIUM ALGINATE; DRUG-RELEASE; DELIVERY; CHITOSAN; MICROSPHERES; FORMULATION; DESIGN;

D O I：

10.1016/j.ijbiomac.2013.08.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The paper describes development of aceclofenac-loaded pectinate-poly(vinyl pyrrolidone) [PVP] beads through ionotropic-gelation. Effects of amount of pectin and PVP on drug encapsulation efficiency (DEE), and cumulative drug release at 6 h (R-6h) were optimized by using response surface methodology. The optimized beads showed DEE of 96.58 +/- 4.15% and R-6h of 41.62 +/- 2.18% with controlled drug release pattern. FTIR spectroscopy analysis revealed possible intermolecular hydrogen bonding, which could be formed between C=O groups of PVP and -OH groups of pectin in these beads. The swelling of these beads were influenced by pH of the medium. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：194 / 202

页数：9

共 36 条

[1]

Application of response surface methodology to formulation of ionotropically gelled gum cordia/gellan beads [J].

Ahuja, Munish ;

Yadav, Monika ;

Kumar, Sumit .

CARBOHYDRATE POLYMERS, 2010, 80 (01) :161-167

[2]

Drug release from calcium and zinc pectinate beads: Impact of dissolution medium composition [J].

Assifaoui, Ali ;

Chambin, Odile ;

Cayot, Philippe .

CARBOHYDRATE POLYMERS, 2011, 85 (02) :388-393

[3]

Preparation, in vitro and in vivo evaluation of algino-pectinate bioadhesive microspheres: An investigation of the effects of polymers using multiple comparison analysis [J].

Chakraborty, Santanu ;

Khandai, Madhusmruti ;

Sharma, Anuradha ;

Khanam, Nazia ;

Patra, Ch. Niranjan ;

Dinda, Subas Chandra ;

Sen, Kalyan Kumar .

ACTA PHARMACEUTICA, 2010, 60 (03) :255-266

[4]

Effects of poly(vinylpyrrolidone) and ethylcellulose on alginate microspheres prepared by emulsification [J].

Chan, LW ;

Heng, PWS .

JOURNAL OF MICROENCAPSULATION, 1998, 15 (04) :409-420

[5]

Properties of tableted high-amylose corn starch-pectin blend microparticles intended for controlled delivery of diclofenac sodium [J].

Desai, Kashappa Goud .

JOURNAL OF BIOMATERIALS APPLICATIONS, 2007, 21 (03) :217-233

[6]

Desai KGH, 2005, AAPS PHARMSCITECH, V6

[7]

Oil-entrapped sterculia gum-alginate buoyant systems of aceclofenac: Development and in vitro evaluation [J].

Guru, Pravat Ranjan ;

Nayak, Amit Kumar ;

Sahu, Rajendra Kumar .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 104 :268-275

[8]

Aceclofenac-loaded chitosan-tamarind seed polysaccharide interpenetrating polymeric network microparticles [J].

Jana, Sougata ;

Saha, Abhimunya ;

Nayak, Amit Kumar ;

Sen, Kalyan Kumar ;

Basu, Sanat Kumar .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2013, 105 :303-309

[9]

Rivastigmine-loaded PLGA and PBCA nanoparticles: Preparation, optimization, characterization, in vitro and pharmacodynamic studies [J].

Joshi, Shrinidh A. ;

Chavhan, Sandip S. ;

Sawant, Krutika K. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2010, 76 (02) :189-199

[10]

Optimization of calcium pectinate gel beads for sustained-release of catechin using response surface methodology [J].

Lee, Ji-Soo ;

Chung, Donghwa ;

Lee, Hyeon Gyu .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2008, 42 (04) :340-347

← 1 2 3 4 →