Asymmetric cyclization-carbonylation of cyclic-2-methyl-2-propargyl-1,3-diols

被引：39

作者：

Kato, K

Tanaka, M

Yamamoto, Y

Akita, H

机构：

[1] Toho Univ, Sch Pharmaceut Sci, Funabashi, Chiba 2748510, Japan

[2] Toho Univ, Fac Sci, Dept Chem, Funabashi, Chiba 2748510, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(02)00049-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of asymmetric cyclization-carbonylation of cyclic-2-methyl-2-propargyl-1,3-diols 1 catalyzed by palladium(II) with chiral bisoxazolines was investigated. The reaction of 1 in the presence of palladium(II)-chiral ligands/p-benzoquinone in methanol at 0 to -45degreesC under carbon monoxide atmosphere (balloon) afforded (E)-bicyclic-beta-alkoxyacrylates 2 in excellent yields with moderate enantioselectivities. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：1511 / 1513

页数：3

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