Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection

被引：65

作者：

Mills, TM ^{[1
]}

Chitaley, K

Lewis, RW

Webb, RC

机构：

[1] Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Surg, Urol Sect, Augusta, GA 30912 USA

[3] Univ Michigan, Dept Physiol, Ann Arbor, MI 48109 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2002年 / 439卷 / 1-3期

关键词：

penile erection; nitric oxide (NO); RhoA/Rho-kinase;

D O I：

10.1016/S0014-2999(02)01408-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The RhoA/Rho-kinase pathway mediates vasoconstriction in the cavernosal circulation. Inhibition of this pathway leads to penile erection in the in vivo rat model, These studies examined the hypothesis that nitric oxide (NO) inhibits RhoA/Rho-kinase signaling as pail of normal erection. The results show that NO causes increased intracavernosal pressure and that this response is potentiated by prior treatment with a threshold dose of the Rho-kinase inhibitor, (+)-(R)-trans-4-(I-Aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide dihydro chloride, monohydrate (Y-27632). These results support the hypothesis that NO inhibits Rho-kinase-induced cavernosal vasoconstriction during erection. (C) 2002 Published by Elsevier Science B.V.

引用

页码：173 / 174

页数：2

共 8 条

[1]

Andersson KE, 2001, PHARMACOL REV, V53, P417

[2] RhoA/Rho-kinase: a novel player in the regulation of penile erection [J].