Physiologic stability and physiologic state

被引:47
作者
Buchman, TG
机构
[1] WASHINGTON UNIV,SCH MED,DEPT SURG,ST LOUIS,MO
[2] WASHINGTON UNIV,SCH MED,DEPT ANESTHESIOL & MED,ST LOUIS,MO
关键词
D O I
10.1097/00005373-199610000-00002
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Several disease states (e,g,, disseminated inflammation) demonstrate physiologic stability: they resolve only slowly and are resistant to both specific and symptomatic therapies. The existence of multiple stable physiologic states, including both health and disease states, is not anticipated by classical, linear descriptions of physiologic control mechanisms, Multiple stable states are, however, predicted by a simple nonlinear model in which the resistance to perturbation derives from interconnections among the model's elements, If the stability of selected disease states derives from nonlinear interactions among cells, tissues, and organs, then some therapies aimed at supporting or normalizing performance of specific organs may be misdirected.
引用
收藏
页码:599 / 605
页数:7
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