Synthesis of Δ4-β-D-glucopyranosiduronic acids as mimetics of 2,3-unsaturated sialic acids for sialidase inhibition

被引：22

作者：

Florio, P ^{[1
]}

Thomson, RJ ^{[1
]}

Alafaci, A ^{[1
]}

Abo, S ^{[1
]}

von Itzstein, M ^{[1
]}

机构：

[1] Monash Univ, Dept Med Chem, Parkville, Vic 3052, Australia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00331-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mimetics of Neu5Ac2en and KDN2en, based on Delta(4)-beta-D-glucopyranosiduronic acids, have been synthesised. The Neu5Ac2en mimetic 5 showed inhibition of both bacterial and viral sialidases, with inhibition of the viral sialidase being comparable to that of Neu5Ac2en itself. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：2065 / 2068

页数：4

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