Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the look locker method

Objective: The objective of this study was to implement a three-dimensional (3-D) T1 mapping sequence (3DLL) at 3.0 T for dGEMRIC based on the Look Locker scheme. Materials and Methods: Because all current reports on dGEMRIC are at 1.5 T and mostly using 2-D IR fast spin echo (FSE), data were acquired at 1.5 T and 3.0 T with both 3DLL and 2-D IR-FSE sequence. Phantoms with different concentrations of Gd(DTPA)2were used and seven subjects (three asymptornatic, four symptomatic) were scanned using the dGEMRIC technique. Results: The T1 measurements obtained on the phantom with 3DLL show very good agreement with those acquired with 2-D IR-FSE. Using a two-tailed paired t test, the TI (Gd) measurements in two sections obtained in all subjects with both sequences were found to be statistically indistinguishable at either field strength (P = 0.07 at 1.5 T and P = 0.07 at 3.0 T). Conclusions: The preliminary data presented here suggest that the 3DLL sequence provides accurate TI values with sufficient in-plane resolution and allows full joint coverage in less than 10 minutes.