Catalytic enantioselective crossed aldehyde-ketone benzoin cyclization

被引：205

作者：

Takikawa, Hiroshi

Hachisu, Yoshifumi

Bode, Jeffrey W.

Suzuki, Keisuke

机构：

[1] Tokyo Inst Technol, Dept Chem, SORST, JST Agcy,Meguro Ku, Tokyo 1528551, Japan

[2] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 21期

关键词：

asymmetric synthesis; C-C coupling; cyclization; N-heterocyclic carbenes; tertiary alcohols;

D O I：

10.1002/anie.200600268

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Joining together: The catalytic, asymmetric benzoin cyclization of a wide variety ketoaldehydes using chiral triazolium salts of type 1 has been carried out (see scheme). The corresponding cyclized products were prepared in high yields and with excellent enantioselectivities. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3492 / 3494

页数：3

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