The hormonal receptor status of uterine carcinosarcomas (mixed Mullerian tumours): An immunohistochemical study

被引:29
作者
Ansink, AC
Cross, PA
Scorer, P
Lopes, AD
Monaghan, JM
机构
[1] QUEEN ELIZABETH HOSP, DEPT PATHOL, GATESHEAD NE9 6SX, TYNE & WEAR, ENGLAND
[2] QUEEN ELIZABETH HOSP, DEPT GYNAECOL ONCOL, GATESHEAD NE9 6SX, TYNE & WEAR, ENGLAND
关键词
hormonal receptor status; uterine mixed Mullerian tumours; uterine carcinosarcomas;
D O I
10.1136/jcp.50.4.328
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Aim-To investigate the role of oestrogen and progesterone receptor status in uterine carcinosarcomas (mixed Mullerian tumours) to see whether the receptors were identifiable, and if so whether they were of significance clinically. Methods-11 cases of uterine carcinosarcoma were identified from clinical and pathology records. An immunohistochemical method was used to demonstrate oestrogen and progesterone hormone receptors on paraffin embedded material, with suitable tissue controls, staining being recorded. Results-10 of 11 cases showed staining for one or both hormone receptors in normal tissue adjacent to tumour. In four carcinosarcoma cases, staining for one or both receptors was shown within the epithelial component (appearing to correlate with the degree of epithelial differentiation); two of these cases had staining within sarcomatous areas. Two of the three patients still alive had epithelial hormone receptor positivity. Conclusions-Receptors for oestrogen and progesterone were found in four of 11 cases of uterine carcinosarcoma, using paraffin embedded material. There may be an association between hormone receptor positivity and clinical outcome.
引用
收藏
页码:328 / 331
页数:4
相关论文
共 21 条
[1]   LOW-GRADE STROMAL SARCOMA - DNA FLOW CYTOMETRIC ANALYSIS AND ESTROGEN PROGESTERONE-RECEPTOR DATA [J].
DUNTON, CJ ;
KELSTEN, ML ;
BROOKS, SE ;
VIGLIONE, MJ ;
CARLSON, JA ;
MIKUTA, JJ .
GYNECOLOGIC ONCOLOGY, 1990, 37 (02) :268-275
[2]  
GAGNE E, 1989, MODERN PATHOL, V2, P433
[3]   MALIGNANT MIXED MULLERIAN TUMOR VERSUS HIGH-GRADE ENDOMETRIAL CARCINOMA AND AGGRESSIVE VARIANTS OF ENDOMETRIAL CARCINOMA - A COMPARATIVE-ANALYSIS OF SURVIVAL [J].
GEORGE, E ;
LILLEMOE, TJ ;
TWIGGS, LB ;
PERRONE, T .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1995, 14 (01) :39-44
[4]  
KAHANPAA KV, 1986, OBSTET GYNECOL, V67, P417
[5]   ENDOMETRIAL STROMAL SARCOMA - A CLINICOPATHOLOGICAL STUDY OF 11 CASES WITH DETERMINATION OF ESTROGEN AND PROGESTIN RECEPTOR LEVELS IN 3 TUMORS [J].
KATZ, L ;
MERINO, MJ ;
SAKAMOTO, H ;
SCHWARTZ, PE .
GYNECOLOGIC ONCOLOGY, 1987, 26 (01) :87-97
[6]   AN IMMUNOHISTOCHEMICAL STUDY OF ESTROGEN AND PROGESTERONE RECEPTORS IN ADENOCARCINOMA OF THE ENDOMETRIUM AND IN THE ADJACENT MUCOSA [J].
KERNER, H ;
SABO, E ;
FRIEDMAN, M ;
BECK, D ;
SAMARE, O ;
LICHTIG, C .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 1995, 5 (04) :275-281
[7]   PROGNOSTIC FACTORS IN EARLY-STAGE UTERINE SARCOMA - A GYNECOLOGIC-ONCOLOGY-GROUP STUDY [J].
MAJOR, FJ ;
BLESSING, JA ;
SILVERBERG, SG ;
MORROW, CP ;
CREASMAN, WT ;
CURRIE, JL ;
YORDAN, E ;
BRADY, MF .
CANCER, 1993, 71 (04) :1702-1709
[8]   ENDOMETRIAL STROMAL SARCOMA OF THE UTERUS [J].
MEDEN, H ;
MEYERRATH, D ;
SCHAUER, A ;
KUHN, W .
ANTI-CANCER DRUGS, 1991, 2 (01) :35-37
[9]   ENDOMETRIAL STROMAL SARCOMA EXPRESSION OF ESTROGEN-RECEPTORS, PROGESTERONE RECEPTORS AND ESTROGEN-INDUCED SRP27 (24K) SUGGESTS HORMONE RESPONSIVENESS [J].
NAVARRO, D ;
CABRERA, JJ ;
LEON, L ;
CHIRINO, R ;
FERNANDEZ, L ;
LOPEZ, A ;
RIVERO, JF ;
FERNANDEZ, P ;
FALCON, O ;
JIMENEZ, P ;
PESTANO, J ;
DIAZCHICO, JC ;
DIAZCHICO, BN .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 41 (3-8) :589-596
[10]  
NISOLLE M, 1994, FERTIL STERIL, V62, P751