Microbial transformation of parthenolide

被引：32

作者：

Galal, AM ^{[1
]}

Ibrahim, ARS ^{[1
]}

Mossa, JS ^{[1
]}

El-Feraly, FS ^{[1
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia

来源：

PHYTOCHEMISTRY | 1999年 / 51卷 / 06期

关键词：

parthenolide; hydroxylation; feverfew; Tanacetum parthenium; Asteraceae; microbial; transformation; NMR;

D O I：

10.1016/S0031-9422(99)00066-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Microbial transformation of the germacranolide parthenolide using Rhizopus nigricans, Streptomyces fulvissimus and Rhodotorula rubra yielded three new compounds: 11 alpha H-dihydroparthenolide, 9 beta-hydroxy-11 beta H-dihydroparthenolide and 14-hydroxy-11 beta H-dihydroparthenolide. 11 beta H-dihydroparthenolide was the only common metabolite produced by all microorganisms. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：761 / 765

页数：5

共 21 条

[1]

ABDELSATTAR E, 1996, J NAT PRODUCTS, V58, P403

[2]

ALSHEDDI E, THESIS

[3]

Parthenolide inhibits the contractile responses of rat stomach fundus to fenfluramine and dextroamphetamine but not serotonin [J].

Bejar, E .

JOURNAL OF ETHNOPHARMACOLOGY, 1996, 50 (01) :1-12

[4]

BREITMAIR E, 1974, 13C NMR SPECTROSCOPY

[5]

BIOMIMETIC TRANSFORMATIONS OF PARTHENOLIDE [J].

CASTANEDAACOSTA, J ;

FISCHER, NH ;

VARGAS, D .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (01) :90-98

[6]

Davis PJ., 1988, DEV IND MICROBIOL, V29, P197

[7]

Fischer N.H., 1991, MODERN PHYTOCHEMICAL

[8]

Antimycobacterial evaluation of germacranolides [J].

Fischer, NH ;

Lu, TS ;

Cantrell, CL ;

Castañeda-Acosta, J ;

Quijano, L ;

Franzblau, SG .

PHYTOCHEMISTRY, 1998, 49 (02) :559-564

[9]

FISCHER NH, 1991, METHODS PLANT BICOH

[10]

Fonken G., 1972, CHEM OXIDATIONS MICR

← 1 2 3 →