Intestinal entry of prions

被引：14

作者：

Ghosh, S ^{[1
]}

机构：

[1] Univ Edinburgh, Gastrointestinal Unit, Dept Med Sci, Western Gen Hosp, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2002年 / 40卷 / 01期

关键词：

prions; variant CJD; laminin receptor protein; small intestine;

D O I：

10.1055/s-2002-19641

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Variant Creutzfeldt-Jakob disease is thought to be caused by infected prion protein via ingestion of contaminated beef. After ingestion of infected prion proteins, uptake by small intestine may be by either M-cell dependent or M-cell independent routes. A receptor for prion protein, laminin receptor precursor is expressed on the brush border of small intestinal epithelium in 40% of subjects. The cellular prion protein expressed on the enteric nervous system might serve as the target for conversion to infectious prion protein and a route for spread to the central nervous system.

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收藏

页码：37 / 39

页数：3

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