A Ratiometric Fluorescent Probe for Cysteine and Homocysteine Displaying a Large Emission Shift

被引：303

作者：

Lin, Weiying ^{[1
]}

Long, Lingliang ^{[1
]}

Yuan, Lin ^{[1
]}

Cao, Zengmei ^{[1
]}

Chen, Bingbing ^{[1
]}

Tan, Wen ^{[1
]}

机构：

[1] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 24期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1021/ol802436j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-(1H-phenanthro[9,10-d]imidazol-2-yl)benzaldehyde 1 was rationally designed as a novel ratiometric fluorescent probe for cysteine and homocysteine. Upon addition of cysteine or homocysteine, notably, the probe displayed a very large (125 nm) hypsochromic shift in emission due to switching off intramolecular charge transfer. This large emission wavelength shift may allow probe 1 to be employed for quantitatively detecting Cys/Hcy.

引用

页码：5577 / 5580

页数：4

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