The ASK1-MAP kinase pathways in immune and stress responses

被引：78

作者：

Hayakawa, Teruyuki ^{[1
]}

Matsuzawa, Atsushi ^{[1
]}

Noguchi, Takuya ^{[1
]}

Takeda, Kohsuke ^{[1
]}

Ichijo, Hidenori ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Cell Signaling, Bunkyo Ku, Tokyo 1130033, Japan

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 04期

关键词：

MAP kinase cascades; apoptosis signal-regulating kinase 1; innate immunity; inflammation; oxidative stresses;

D O I：

10.1016/j.micinf.2005.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：1098 / 1107

页数：10

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