Effect of formulation and process variables on the formation of chitosan-gelatin coacervates

被引：60

作者：

RemunanLopez, C ^{[1
]}

Bodmeier, R ^{[1
]}

机构：

[1] UNIV TEXAS, COLL PHARM, AUSTIN, TX 78712 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 135卷 / 1-2期

关键词：

chitosan; complex coacervation; gelatin type B; microencapsulation;

D O I：

10.1016/0378-5173(95)04347-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The formation of complex coacervates between the oppositely charged polyions, chitosan and type B gelatin, was investigated. The complex formation was rapid and only observed al very diluted chitosan concentrations over a narrow pH range. The optimum chitosan-gelatin ratio was found to be 1:10 to 1:20, above or below which the coacervate yield decreased significantly. The coacervate yield decreased at higher temperatures and increased ionic strength. Complex coacervation was found to be dependent upon the molecular weight and bloom strength of the polymers. Several model compounds (clofibrate, piroxicam, sulfamethoxazole) were successfully encapsulated within the chitosan-gelatin coacervates.

引用

页码：63 / 72

页数：10

共 30 条

[1] A NOVEL-APPROACH TO THE ORAL DELIVERY OF MICRO-PARTICLES OR NANOPARTICLES [J].